Interaction of DNA and RNA with metal ions

• Introduction
• Binding of metal ions with DNA, synthetic polydeoxynucleotides and synthetic polyribonucleotides
  • Association constants
  • Binding characteristics
• Effects of metal ion binding on conformation of DNA
  • Helix coil transition (melting temperature) for Li(I)…Cs(I)
  • Helix coil transition (melting temperature) for Cs(I)…U(IV)
  • Transition between right- and left-handed helix
  • Other conformational changes: secondary (except right-left handed), tertiary, quaternary structures
  • Hydrodynamic property changes
• Binding of metal ions with RNA
  • Types of metal ion binding sites in tRNAs
  • Details of binding sites for metal ions Mg(II)…Cu(II) in tRNS
  • Details of binding sites for metal ions Zn(II)…Cs(I) in tRNS
  • RNS other than tRNS
  • Association constants for metal ion-tRNA interactions
• Effects of metal ion binding on conformation of RNA
  • Effects on secondary structure
  • Effects on tertiary structures
  • Thermal melting effects - tRNAs
• Data on metal ion catalyzed degradation of RNAs and polyribonucleotides
  • Order of reactivity
  • Degradation rate for ions Mg(II)…La(III)
  • Degradation rate for ions Ce(III)…Bi(III)
• Data on metal ion catalyzed degradation of DNAs and polydeoxynucleotides
• Figures
• References